...It could also be "multiply the numbers on the 'to the right' diagonal, divide the numbers on the 'to the left diagonal', and add: 5*3 + (2/2) = 15 + 1 = 16". Then you have to check to see if there are any numbers that would allow you to mirror this pattern in the second box.
For instance, for my first rule to work, there would have to be some number so that (?)*3 + 9*3 = 3*? + 27 = 67, so 3*? = 40. But is there any whole number (which is what I'm assuming you're supposed to use) that gives you 40 when you multiply by 3? No, so this can't possibly be "the" correct answer. For my second to work, there would have to be some number so that 9*3 + (?/3) = 27 + (?/3) = 27 + ?/3 = 67, so ?/3 = 40. Is there any number that gives you 40 after you divide it by 3? If so, then this is a mathematically valid rule, and it might be "the" right answer. If not, then keep trying.