Can someone help me with that ??

What were the instructions that accompanied this problem? Since there's no equals sign, I'm assuming the instructions were something like "Simplify the following expression." Assuming that's the correct instructions, my basic process would be to deal with the fraction subtraction in parentheses, FOIL out the multiplications where appropriate, and then do the arithmetic operations according to PEMDAS (or perhaps you learned BODMAS?) The real question is, what have you tried? Where are you stuck? The more specific you can be about what's giving you trouble, the better help we can provide. Thank you.
 
You have 18(a2)6(a4)+4(a214)8a42+45a2a3a+34(8a+4)35,5\displaystyle 18(a- 2)- 6(-a- 4)+ 4(\frac{a}{2}- \frac{1}{4})- \frac{8a- 4}{2}+ 4*5a- 2a- 3a+ \frac{3}{4}(8a+ 4)- 35,5

(I assume that your "35,5" is what I would write "35.5".)

Do you know the "distributive law"? That says that 18(a- 2)= 18a- 36 and that -6(-a-4)= 6+ 24. Surely, you can see that 8a42=4a2\displaystyle \frac{8a- 4}{2}= 4a- 2? And that 34(8a+4)=38a+44=3(2a+1)=6a+3\displaystyle \frac{3}{4}(8a+ 4)= 3\frac{8a+ 4}{4}= 3(2a+ 1)= 6a+ 3? What about 4(a214)\displaystyle 4(\frac{a}{2}- \frac{1}{4})? Do you see that that is equal to 4a244\displaystyle \frac{4a}{2}- \frac{4}{4}? Do you know how to "reduce" that?
 
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