I am assuming you mean
4915!∗5000!4965!∗4950!=4915!∗4950!∗(i=4951∏5000i)4915!∗(i=4916∏4965i)∗4950!=i=4951∏5000ii=4916∏4965i=(i=4951∏4965)(i=4966∏5000i)(i=4916∏4950i)(i=4951∏4965i)=i=4966∏5000ii=4916∏4950i=i=4916∏4950(i+50i).
Now a hand calculator will handle multiplying all those fractions correctly, no overflow. But is easy to make a mistake, and it is slow. A spreadsheet is much quicker and much less error prone.
Edit: 4916 / 4966 = 0.9899. And 4950 / 5000 = 0.99. So
4915!∗5000!4965!∗4950!=i=4916∏4950(i+50i)≈0.9935≈0.70.