PLZ HELP MEEEEE(factoring)

The first one probably has a minus sign missing (16+25x^2 can't be factorised). In which case, both are a disguised difference of two squares: \(\displaystyle \mbox{a^2 - b^2 = (a + b)(a - b)}\).

Give it a shot.

Don't forget to show your work if need be.
 
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